SIGN-R1 Recombinant Rabbit Monoclonal Antibody (001), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA530247-Each-of-1 | In Stock | ₹ 41,385.00 |
PIMA530247 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,385.00
GST (18%): ₹ 7,449.30
Total Price: ₹ 48,834.30
Antigen
SIGN-R1
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative
Gene Accession No.
Q8CJ91, Q91ZX1
Gene Symbols
Cd209a, Cd209b
Immunogen
Recombinant Mouse SIGNR1/CD209b protein
Quantity
100μL
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG
Applications
ELISA
Clone
001
Conjugate
Unconjugated
Gene
Cd209b
Gene Alias
1810030I22Rik; CD209; CD209 antigen-like protein A; CD209 antigen-like protein B; Cd209a; CD209a antigen; CD209a molecule; Cd209b; CD209b antigen; CDSIGN; CIRE; DC SIGNR1; Dcsign; DC-SIGN; DC-SIGN1; DC-SIGNR1; DC-SIGN-related protein 1; Dendritic cell-specific ICAM-3-grabbing non-integrin; MGC130443; mSIGNR1; OtB7; SIGNR1; SIGN-R1; SIGNR5
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
170786, 69165
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- This product is preservative free
- It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- This antibody has specificity for Mouse SIGNR1/CD209b
- SIGNR1 is a type II transmembrane C-type lectin that was identified in a search for mouse homologues of human DC-SIGN
- It is expressed at high levels in splenic marginal zone macrophages and lymph node medullary macrophages, where it functions to uptake dextran polysaccharides, including the capsular polysaccharide of Streptococcus pneumoniae
- It has also been demonstrated that SIGNR1 physically associates with TLR4/MD2, and it has been suggested that this association plays a role in recognition of LPS
- Furthermore, recently it has been shown that SIGNR1 deficient mice have a defect in catabolism of the complement component C3, and that SIGNR1 binds directly to the complement C1 subcomponent, C1q to assemble a non-conventional C3 convertase.