Dectin 2 Recombinant Rabbit Monoclonal Antibody (1), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA530299-Each-of-1 | In Stock | ₹ 41,385.00 |
PIMA530299 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,385.00
GST (18%): ₹ 7,449.30
Total Price: ₹ 48,834.30
Antigen
Dectin 2
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative
Gene Accession No.
Q9JKF4
Gene Symbols
CLEC6A
Immunogen
Recombinant Mouse CLEC4N protein (Ile44-Leu209)
Quantity
100μL
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG
Applications
ELISA
Clone
1
Conjugate
Unconjugated
Gene
CLEC6A
Gene Alias
Clec4n; CLEC6A; Clec6a-ps1; CLECSF10; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 10; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10; C-type lectin domain family 4, member n; C-type lectin domain family 6 member A; C-type lectin domain family 6, member A; C-type lectin domain family 6, member A, pseudogene 1; C-type lectin superfamily member 10; DC-associated C-type lectin 2; dectin 2; DECTIN2; dectin-2; Dectin-2p; Dendritic cell-associated C-type lectin 2; natural killer complex lectin; Nkcl
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
56620
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- This product is preservative free
- It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- This antibody has specificity for Mouse CLEC4N/CLEC6A/Dectin-2
- Dectin-2 is a C-type lectin expressed by dendritic cells, macrophages and inflammatory monocytes
- It is a type II membrane receptor, with a short cytoplasmic tail, and a C-terminal C-type lectin domain
- Dectin-2 is a receptor with specificity for high mannose structures and mediates cytokine production from DC and other antigen presenting cells
- Though, Dectin-2 has no obvious signaling motifs attached to CP tail, reports indicate that Dectin-2 employs FcRg for internalization and to activate NF-kappaB pathway for cytokine production
- Though it shares only 20-25% of homology with Dectin-1, it functions similarly as pattern recognition receptor (PRR) for fungal infections, to activate both innate (Syk-CARD9 innate signaling pathway) and adaptive immune responses (by activation of DC) to fungal infections
- Thus Dectin-2 is a connector molecule of both innate and adaptive immunity functioning at DC level.