FGF19 Recombinant Rabbit Monoclonal Antibody (032), Invitrogen™

Description

• This product is preservative free
• It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
• The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
• Then, individual clones are screened to select the best candidates for production
• The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
• This antibody has specificity for Human FGF19/FGF-19
• FGF19, Fibroblast growth factor 19, is a protein that in humans is encoded by the FGF19 gene
• The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family
• The FGF19 gene is mapped to 11q13.3
• The deduced 216-amino acid FGF19 protein contains asignal sequence and 2 cysteine residues that are conserved in the FGF family
• Expression of this gene was detected only in fetal but not adult brain tissue
• Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development
• FGF19 stimulates hepatic protein and glycogen synthesis but does not induce lipogenesis
• The effects of FGF19 are independent of the activity of either insulin or the protein kinase Akt and, instead, are mediated through a mitogen-activated protein kinase signaling pathway that activates components of the protein translation machinery and stimulates glycogen synthase activity
• The orthologous protein in mouse is FGF15, which shares about 50% amino acid identity and has similar functions
• Together they are often referred to as FGF15/19.