GFR alpha-1 Recombinant Rabbit Monoclonal Antibody (029), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA530610-Each-of-1 | In Stock | ₹ 41,385.00 |
PIMA530610 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,385.00
GST (18%): ₹ 7,449.30
Total Price: ₹ 48,834.30
Antigen
GFR alpha-1
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative
Gene Accession No.
Q62997
Gene Symbols
GFRA1
Immunogen
Recombinant Rat GFRA1 protein (Met1-Leu445)
Quantity
100μL
Primary or Secondary
Primary
Target Species
Rat
Product Type
Antibody
Isotype
IgG
Applications
ELISA
Clone
029
Conjugate
Unconjugated
Gene
GFRA1
Gene Alias
AU042498; DKFZp313E1012; DKFZp686J0156; FLJ10561; FLJ31546; GDNF family receptor alpha 1; GDNF family receptor alpha-1; GDNF receptor alpha; GDNF receptor alpha-1; GDNFR; GDNFRA; GDNFR-alpha; GDNFR-alpha-1; gfr alpha 1; GFR alpha-1; GFRA1; GFR-alpha-1; glial cell line derived neurotrophic factor family receptor alpha 1; Glial cell line-derived neurotrophic factor receptor alpha; GPI-linked anchor protein; MGC23045; PI-linked cell-surface accessory protein; RET ligand 1; RET1L; RETL1; TGF-beta-related neurotrophic factor receptor 1; TRNR1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
25454
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- This product is preservative free
- It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- This antibody has specificity for Rat GFRA1
- Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system
- Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha, which is a cell surface receptor for GDNF
- The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently
- GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFR-a-1 recently
- GFR-a-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK)
- Thus, GDNF, GFR-a and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.