PIMA530803
PTS Monoclonal Antibody (02), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA530803-Each-of-1 | In Stock | ₹ 32,485.00 |
PIMA530803 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 32,485.00
GST (18%): ₹ 5,847.30
Total Price: ₹ 38,332.30
Antigen
PTS
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative
Gene Accession No.
Q03393
Gene Symbols
Pts
Immunogen
Recombinant Human PTS Protein (Met1-Glu145)
Quantity
100μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
ELISA
Clone
02
Conjugate
Unconjugated
Gene
Pts
Gene Alias
6-pyruvoyl tetrahydrobiopterin synthase; 6-pyruvoyltetrahydropterin synthase; 6-pyruvoyl-tetrahydropterin synthase; PTP synthase; PTPS; PTS
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
5805
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- This product is preservative free
- It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
- This antibody has specificity for Human PTS
- The tetrahydrobiopterin (BH4) cofactor is essential for hepatic hydroxylase, which is involved in phenylalanine degradation and catecholamine and serotonin biosynthesis
- BH4 is also an essential and limiting cofactor for all types of nitric oxide synthase
- BH4 deficiency results in hyperphenylalaninemia and monoamine neurotransmitter depletion and is most commonly due to autosomal recessive mutation in 6-pyruvoyltetrahydropterin synthase (PTPS), the second enzyme for BH4 biosynthesis
- The active site of PTPS consists of the pterin-anchoring Glu A107 neighbored by two catalytic motifs: a Zn(II) binding site and an inter-subunit catalytic triad formed by Cys A42, Asp B88 and His B89
- The active site of PTPS undergoes a Zn and Mg-dependent reaction that includes a triphosphate elimination, a stereospecific reduction and the oxidation of both side hydroxyl groups
- The catalytic triad of PTPS is involved in the deprotonation of the side-chain carbons of substrates
- In addition, Ser 19 of human PTPS may be a substrate for cGMP-dependent protein kinase type II phosphorylation in vivo, which is essential for normal activity of PTPS.