KChIP3 Recombinant Rabbit Monoclonal Antibody (011), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA530946-Each-of-1 | In Stock | ₹ 41,385.00 |
PIMA530946 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,385.00
GST (18%): ₹ 7,449.30
Total Price: ₹ 48,834.30
Antigen
KChIP3
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative
Gene Accession No.
Q9Y2W7
Gene Symbols
Kcnip3
Immunogen
Recombinant Human CSEN/calsenilin/KCNIP3 Protein (Met1-Ile256)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
ELISA
Clone
011
Conjugate
Unconjugated
Gene
Kcnip3
Gene Alias
4933407H12Rik; AI413860; A-type potassium channel modulating protein 3; A-type potassium channel modulatory protein 3; Calsenilin; calsenilin presenilin-binding protein EF hand transcription factor; calsenilin, presenilin binding protein, EF hand transcription factor; calsenilin, presenilin-binding protein, EF hand transcription fa; calsenilin, presenilin-binding protein, EF hand transcription factor; CSEN; downstream regulatory element-antagonist modulator; DREAM; DRE-antagonist modulator; KChIP3; KCNIP3; Kv channel interacting protein 3; Kv channel interacting protein 3, calsenilin; kv channel-interacting protein 3; potassium channel interacting protein 3; potassium voltage-gated channel interacting protein 3; R74849; rKChIP3
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
30818
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- This product is preservative free
- It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- This antibody has specificity for Human CSEN/calsenilin/KCNIP3
- Voltage-gated potassium (Kv) channels are key components of the potassium currents in the heart and central nervous system
- In the heart, Kv4 channels are involved in the repolarization phase of the action potential
- In the brain however, these channels prevent reverse-propagation of action potentials
- Found associated with Kv4 channels are a group of calcium-binding proteins termed KChIPs (Kv channel interacting proteins)
- KChIPs are small molecular weight proteins that bind to the cytoplasmic amino termini of Kv4 alpha-subunits and help to modulate its function
- There are currently three known KChIPs; KChIP1 expressed in the brain; KChIP2 expressed in the brain, heart, and lung, and has three isoforms, a, b, and c; and KChIP3, also known as calsenilin and DREAM (downstream regulatory elements (DRE)-antagonist modulator) which is expressed in the brain and testis
- KChIP3 has activities beyond the modulation of Kv4 currents
- It has been shown that KChIP3 binds to the regulatory DRE and represses transcription from the early-response gene c-fos
- Thus, KCHiP3 is the first known calcium-binding protein to function as a DNA-binding transcriptional regulator
- KChIP3 is also found associated with the presenilins and is implicated in the mediation of beta-amyloid formation.