PIMA531052
MCPT-1 Recombinant Rabbit Monoclonal Antibody (43), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA531052-Each-of-1 | In Stock | ₹ 41,385.00 |
PIMA531052 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,385.00
GST (18%): ₹ 7,449.30
Total Price: ₹ 48,834.30
Antigen
MCPT-1
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative
Gene Accession No.
P11034
Gene Symbols
Mcpt1
Immunogen
Recombinant Mouse MCPT1 protein (Met1-Lys246)
Quantity
100μL
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG
Applications
ELISA
Clone
43
Conjugate
Unconjugated
Gene
Mcpt1
Gene Alias
AV080368; mast cell protease 1; Mcp-1; Mcpt1; mMCP-1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
17224
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- This product is preservative free
- It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- This antibody has specificity for Mouse MCPT-1/MCP-1
- MCPT-1 is the only chymase expressed by intestinal mucosal mast cells, which are found in the intestinal epithelium
- Although it is expressed constitutively and is detectable in the sera of normal mice, parasites in the gut cause systemic levels to increase dramatically within two days and peak at two weeks following infection
- It plays an important role in host defense against intestinal parasites, as mice deficient in MCPT-1 display delayed response upon infection
- Elevated MCPT-1 levels are also observed during intestinal allergic hypersensitivity reactions
- The mechanism of its action is not fully understood, although it is believed to increase intestinal permeability similarly to rMCPT-II, possibly by cleaving the proteins at tight junctions between cells.