PIMA532376
STIM1 Recombinant Rabbit Monoclonal Antibody (SD0814), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532376-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532376 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
STIM1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P70302, P84903, Q13586
Gene Symbols
STIM1
Immunogen
Recombinant protein within Human Stromal aa 561-685
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry, Western Blot
Clone
SD0814
Conjugate
Unconjugated
Gene
STIM1
Gene Alias
D11S4896E, GOK, IMD10, RGD:1306831}, SIM, Stim1, stim1 {ECO:0000312, STIM1L, STRMK, Stromal interaction molecule 1, stromal interaction molecule 1 precursor, TAM, TAM1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
20866, 361618, 6786
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- STIM1 (stromal interacting molecule; also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane
- Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm
- However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet
- Many questions also remain to be solved around STIM1 functional distribution
- It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.