PIMA532411
HDAC8 Recombinant Rabbit Monoclonal Antibody (SD082-07), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532411-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532411 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
HDAC8
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
B1WC68, Q8VH37, Q9BY41
Gene Symbols
HDAC8
Immunogen
Synthetic peptide within Human HDAC8 aa 61-110
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Western Blot
Clone
SD082-07
Conjugate
Unconjugated
Gene
HDAC8
Gene Alias
2610007D20Rik, CDA07, CDLS5, HD8, Hdac8, HDACL1, histone deacetylase 8, histone deacetylase-like 1, MRXS6, RGD1562895, RPD3, WTS
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
363481, 55869, 70315
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin
- The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones
- Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA
- Conversely, the deacetylation of histones is associated with transcriptional silencing
- Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250
- Mammalian HDAC8, isolated from human kidney, is a histone deacetylase that shares homology to other HDACs but has different tissue distribution
- HDAC8 is localized to the nucleus and plays a role in the development of a broad range of tissues and in the etiology of cancer.