Carbonic Anhydrase IX Recombinant Rabbit Monoclonal Antibody (JJ088-9), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532457-Each-of-1 | In Stock | ₹ 58,295.00 |
PIMA532457 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 58,295.00
GST (18%): ₹ 10,493.10
Total Price: ₹ 68,788.10
Antigen
Carbonic Anhydrase IX
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
Q16790
Gene Symbols
CA9
Immunogen
Recombinant protein within Human Carbonic anhydrase 9 aa 184-276
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry, Western Blot
Clone
JJ088-9
Conjugate
Unconjugated
Gene
CA9
Gene Alias
Ca9, CA-9, CAIX, CA-IX, Car9, Carbonate dehydratase IX, carbonic anhydrase 9, Carbonic anhydrase IX, carbonic dehydratase, G250, Membrane antigen MN, membrane antigen MN homolog, MN, MN/CA9, P54 / 58N, P54/58N, pMW1, RCC-associated antigen G250, RCC-associated protein G250, renal cell carcinoma-associated antigen G250
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
768
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions
- It is abundant in all mammalian tissues
- There are many genes that are inducible by hypoxia, via HIF-1 alpha
- CA IX is one of the most inducible genes because of its stability and location within the membrane
- Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux
- The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia
- Therefore, CA IX has become a reliable histochemical marker of hypoxia.