FOXO4 Recombinant Rabbit Monoclonal Antibody (JJ09-11), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532469-Each-of-1 | In Stock | ₹ 46,413.50 |
PIMA532469 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,413.50
GST (18%): ₹ 8,354.43
Total Price: ₹ 54,767.93
Antigen
FOXO4
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P98177, Q9WVH3
Gene Symbols
FOXO4
Immunogen
Recombinant protein within Human FOXO4 aa 456-505
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Western Blot, Western Blot
Clone
JJ09-11
Conjugate
Unconjugated
Gene
FOXO4
Gene Alias
AFX, Afx1, Afxh, AFXzeta, Fkhr3, Fork head domain transcription factor AFX1, forkhead box O4, forkhead box protein O4, forkhead protein, FOXO4, FOXO4b, MGC120490, MLLT7, myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila), translocated to, 7, OTTHUMP00000023497, RGD1561201
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
302415, 4303, 54601
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- FOXO4 (Forkhead box O4) is encoded by the FOXO4 gene located on the X chromosome
- It is also known as AFX1 or MLLT7 (Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Translocated To, 7) and is a member of the O class of forkhead/ winged helix family of transcription factors along with FOXO1, FOXO3 and FOXO6
- FOXO4 is abundantly expressed in skeletal muscle and adipose tissue
- FOXO4 binds to the Insulin Responsive Element (IRE) and activates downstream targets of Insulin/IGF1 signaling such as IGFBP1
- However, the activation of another downstream target of the Insulin/IGF1 pathway, Akt, leads to phosphorylation of FOXO4 on specific Ser/Thr residues
- This phosphorylation mediates binding of FOXO4 to 14-3-3 and eventual exit of FOXO4 from the nucleus.