MKP-1 Recombinant Rabbit Monoclonal Antibody (JJ0930), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532480-Each-of-1 | In Stock | ₹ 46,413.50 |
PIMA532480 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,413.50
GST (18%): ₹ 8,354.43
Total Price: ₹ 54,767.93
Antigen
MKP-1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P28562, P28563, Q64623
Gene Symbols
Dusp1
Immunogen
Synthetic peptide within Human DUSP1 aa 112-156
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunohistochemistry, Western Blot
Clone
JJ0930
Conjugate
Unconjugated
Gene
Dusp1
Gene Alias
3ch134, 3CH134/CL100 PTPase, CL 100, CL100, dual specificity phosphatase 1, dual specificity protein phosphatase 1, Dual specificity protein phosphatase hVH1, DUS1, DUSP1, EC 3.1.3.16, EC 3.1.3.48, erp, HVH1, MAP kinase phosphatase 1, MAP kinase phosphatase-1, mitogen-activated protein (MAP) kinase phosphatase-1, mitogen-activated protein kinase phosphatase 1, mitogen-activated protein kinase phosphatase-1, MKP1, mkp-1, oxidative stress-inducible protein tyrosine phosphatase, protein tyrosine phosphatase non-receptor type 16, protein tyrosine phosphatase, non-receptor type 16, protein-tyrosine phosphatase 3CH134, Protein-tyrosine phosphatase CL100, protein-tyrosine phosphatase ERP, Protein-tyrosine phosphatase non-receptor type 16, PTPN10, Ptpn16, serine/threonine specific protein phosphatase, U19515, VH1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
114856, 1843, 19252
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors
- It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus
- The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues
- Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes
- Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.