NUMB Recombinant Rabbit Monoclonal Antibody (JM10-023), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532568-Each-of-1 | In Stock | ₹ 53,088.50 |
PIMA532568 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,088.50
GST (18%): ₹ 9,555.93
Total Price: ₹ 62,644.43
Antigen
NUMB
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P49757, Q2LC84, Q9QZS3
Gene Symbols
Numb
Immunogen
Synthetic peptide within Human NUMB aa 4-47
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
JM10-023
Conjugate
Unconjugated
Gene
Numb
Gene Alias
c14_5527, C14orf41, h-Numb, mnb, m-Nb, m-numb, Nb, NUMB, NUMB endocytic adaptor protein, numb gene homolog, numb gene homolog (Drosophila), numb homolog, numb homolog (Drosophila), NUMB isoform 3, Numb variant 1, Numb variant 2, NUMB, endocytic adaptor protein, protein numb homolog, Protein S171, PTB domain protein, S171
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
18222, 29419, 8650
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells
- Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex
- NUMB is also expressed in postmitotic neurons and plays a role in axonal growth
- Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.