TDP-43 Recombinant Rabbit Monoclonal Antibody (JM51-10), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532627-Each-of-1 | In Stock | ₹ 53,088.50 |
PIMA532627 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,088.50
GST (18%): ₹ 9,555.93
Total Price: ₹ 62,644.43
Antigen
TDP-43
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
Q13148, Q921F2
Gene Symbols
TARDBP
Immunogen
Synthetic peptide within Human TDP43 aa 354-390
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat, Zebrafish
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot, Western Blot
Clone
JM51-10
Conjugate
Unconjugated
Gene
TARDBP
Gene Alias
1190002A23Rik, ALS10, C85084, hypothetical protein, OTTHUMP00000002171, OTTHUMP00000002173, RCJMB04_5g9, RP4-635E18.2, TAR DNA binding protein, TAR DNA binding protein L homeolog, TAR DNA-binding protein 43, TAR DNA-binding protein-43, tardbp, tardbp.L, Tdp43, TDP-43, wu:fb77f02, wu:fc52g10, XELAEV_18035188mg
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
230908, 23435, 298648, 325052
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR
- Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3"ee; splice site
- A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U)
- TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.