CTCF Recombinant Rabbit Monoclonal Antibody (JM10-61), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532640-Each-of-1 | In Stock | ₹ 46,413.50 |
PIMA532640 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,413.50
GST (18%): ₹ 8,354.43
Total Price: ₹ 54,767.93
Antigen
CTCF
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P49711, Q61164, Q9R1D1
Gene Symbols
CTCF
Immunogen
Synthetic peptide within Human CTCF aa 685-727
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat, Zebrafish
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot, Western Blot
Clone
JM10-61
Conjugate
Unconjugated
Gene
CTCF
Gene Alias
11 zinc finger transcriptional repressor, 11-zinc finger protein, AW108038, CCCTC-binding factor, CCCTC-binding factor (zinc finger protein), Ctcf, ctcf protein, CTCFL paralog, im:7152666, MRD21, OTTHUMP00000197610, Transcriptional repressor CTCF, Unknown (protein for IMAGE:8125283)
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
10664, 13018, 415104, 83726
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Transcriptional factor CTCF is a ubiquitously expressed 11-zinc finger domain containing, DNA-binding nuclear phosphoprotein that is involved in multiple aspects of normal gene regulation including transcriptional repression and activation, gene silencing, chromatin insulation and regulation of imprinted sites
- CTCF uses different combinations of ZF domains and interacts with the CCCTC motif on the DNA
- It can bind to HAT- and HDAC-containing complexes thereby influencing transcriptional activation or repression respectively
- It is a multifunctional protein involved in the transactivation of APPB gene, silencing of c-myc gene, and insulation of human beta-globin and DMI myotonic dystrophy locus and imprinting control of IGF2 and H19 regions
- CTCF has also been shown to regulate the transcription of Pax6 and IRAK2 promoter thereby opening a therapeutic avenue
- Mutations in this gene have been associated with invasive breast cancers, prostate cancers and Wilms' tumors.