PIMA532679
NOXA Recombinant Rabbit Monoclonal Antibody (JA30-03), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532679-Each-of-1 | In Stock | ₹ 47,659.50 |
PIMA532679 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,659.50
GST (18%): ₹ 8,578.71
Total Price: ₹ 56,238.21
Antigen
NOXA
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
Q13794
Gene Symbols
PMAIP1
Immunogen
Synthetic peptide within Human Noxa aa 5-54
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunohistochemistry, Western Blot
Clone
JA30-03
Conjugate
Unconjugated
Gene
PMAIP1
Gene Alias
adult T cell leukemia-derived PMA-responsive, APR, Immediate-early-response protein APR, Noxa, Phorbol-12-myristate-13-acetate-induced protein 1, PMA-ind, PMA-induced protein 1, Pmaip1, Protein Noxa
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
5366
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Apoptosis is related to many diseases and development
- The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA
- A new p53 target gene, Noxa, was recently identified, which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins
- Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins
- X-ray irradiation increased p53-dependent Noxa mRNA and protein levels
- Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9
- Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53
- Noxa and PUMA may represent direct mediators of p53-induced apoptosis
- Increased levels of p53 and its target gene Noxa was found in the impaired tumor development.