SATB2 Recombinant Rabbit Monoclonal Antibody (JM52-44), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532788-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532788 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
SATB2
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
Q8VI24, Q9UPW6
Gene Symbols
SATB2
Immunogen
Synthetic peptide within Human SATB2 238-287
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
JM52-44
Conjugate
Unconjugated
Gene
SATB2
Gene Alias
DNA-binding protein SATB2, FLJ21474, FLJ32076, GLSS, KIAA1034, KIAA1034-like DNA binding protein, MGC119474, MGC119477, mKIAA1034, RGD1562369, SATB family member 2, SATB homeobox 2, SATB2, special AT-rich sequence binding protein 2, special AT-rich sequence-binding protein 2, two cut domains-containing homeodomain protein
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
212712, 23314, 501145
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold associated regions
- It is thought to recognize the sugar-phosphate structure of double-stranded DNA
- SATB2 is a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling
- It also acts as a docking site for several chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers
- SATB2 is required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes - probably by modulating BCL11B expression
- It is a repressor of Ctip2 and a regulatory determinant of corticocortical connections in the developing cerebral cortex
- Mutations in the gene are associate with cleft palate isolated (CPI).