p23 Recombinant Rabbit Monoclonal Antibody (JU09-31), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532825-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532825 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
p23
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P83868, Q15185, Q9R0Q7
Gene Symbols
Ptges3
Immunogen
Synthetic peptide within Human p23 aa 43-92
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot, Western Blot
Clone
JU09-31
Conjugate
Unconjugated
Gene
Ptges3
Gene Alias
5730442A20Rik, Co chaperone p23, cPGES, cytosolic prostaglandin E synthase, cytosolic prostaglandin E2 synthase, Hsp90 co chaperone, Hsp90 co-chaperone, LOC100351480, P23, p23 cochaperone, progesterone receptor, progesterone receptor complex p23, Prostaglandin E synthase 3, prostaglandin E synthase 3 (cytosolic), prostaglandin-E synthase 3, Ptges, PTGES3, ptges3 {ECO:0000250, RGD1561913, sid 3177, Sid3177, Tebp, telomerase binding protein, p23, telomerase-binding protein p23, unactive progesterone receptor, 23 kD, UniProtKB:Q15185}
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
10728, 362809, 56351
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone
- Prior to activation, steroid receptors associate with a number of different proteins in both a stable and transient fashion
- Steroid receptor complex proteins include heat shock proteins (HSP70 and HSP90), immunosuppressant binding proteins called immunophilins (the FK506 binding proteins, FKBP52 & FKBP54 and the cyclosporin binding protein, CyP-40) and at least three other proteins termed p23, p60 and p48
- p23 along with HSP70, HSP90 and p60, combine with progesterone receptor (PR) as members of a transient intermediate complex
- Cloned human p23 encodes a protein of 160 amino acids that is highly conserved between species and shows no homology to previously identified proteins
- p23 is a highly acidic phosphoprotein with an aspartic acid-rich C-terminal domain and multiple potential phosphorylation sites
- In vitro studies have suggested that p23 binds to HSP90 and is necessary for the binding of HSP90 and CyP-40 to PR
- While neither its exact function nor mechanism of action have been identified, p23 appears to be an important factor in PR function.