PIEZO1 Monoclonal Antibody (2-10), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532876-Each-of-1 | In Stock | ₹ 49,261.50 |
PIMA532876 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,261.50
GST (18%): ₹ 8,867.07
Total Price: ₹ 58,128.57
Antigen
PIEZO1
Classification
Monoclonal
Concentration
2 mg/mL
Formulation
PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
E2JF22, Q92508
Gene Symbols
Piezo1
Immunogen
Recombinant protein within Human Protein FAM38A aa 1275-1540
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG2a
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
2-10
Conjugate
Unconjugated
Gene
Piezo1
Gene Alias
9630020g22, DHS, Fam38a, family with sequence similarity 38, member A, KIAA0233, LMPH3, Membrane protein induced by beta-amyloid treatment, Mib, mKIAA0233, piezo type mechanosensitive ion channel component 1, Piezo1, piezo-type mechanosensitive ion channel component 1, Protein FAM38A, protein PIEZO1
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
234839, 9780
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Mouse Monoclonal Antibody Piezo1 is a pore-forming subunit of a mechanosensitive non-specific cation channel, and generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium
- Structurally, Piezo1 contains 36 transmembrane domains and functions as a homotetramer
- Piezo1 plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling
- In the kidney, Piezo1 may contribute to the detection of intraluminal pressure changes and to urine flow sensing
- Piezo1 acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation and plays a key role in blood vessel formation and vascular structure in both development and adult physiology
- The protein encoded by the Piezo1 gene is a mechanically-activated ion channel that links mechanical forces to biological signals
- Defects in this gene have been associated with dehydrated hereditary stomatocytosis
- Diseases associated with PIEZO1 include Dehydrated Hereditary Stomatocytosis with/without Pseudohyperkalemia And/Or Perinatal Edema and Lymphedema.