PIMA532884
GRAMD1A Monoclonal Antibody (1-E4), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532884-Each-of-1 | In Stock | ₹ 46,413.50 |
PIMA532884 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,413.50
GST (18%): ₹ 8,354.43
Total Price: ₹ 54,767.93
Antigen
GRAMD1A
Classification
Monoclonal
Concentration
2 mg/mL
Formulation
PBS with 0.2% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
Q8VEF1, Q96CP6
Gene Symbols
GRAMD1A
Immunogen
Recombinant protein within Human GRAMD1A aa 1-724
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgM
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
1-E4
Conjugate
Unconjugated
Gene
GRAMD1A
Gene Alias
1300003M23Rik, AI415002, AW547240, D7Bwg0611e, GRAM domain containing 1A, GRAM domain-containing protein 1A, GRAMD1A, KIAA1533, Protein Aster-A
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
52857, 57655
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Mouse Monoclonal Antibody Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER)
- Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER
- Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol
- In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain
- At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER
- May play a role in tumor progression
- Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192)
- This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192)
- [UniProt]