c-Fos Recombinant Rabbit Monoclonal Antibody (RM374), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA533035-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA533035 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
c-Fos
Classification
Recombinant Monoclonal
Concentration
0.05 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.
P01100
Gene Symbols
FOS
Immunogen
A peptide corresponding to the N-terminus of human Proto-oncogene c-Fos.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
RM374
Conjugate
Unconjugated
Gene
FOS
Gene Alias
activator protein 1, AP-1, cellular oncogene c-fos, cellular oncogene fos, cFos, C-FOS, c-fos oncogene, c-fos protooncogene protein, D12Rfj1, FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS), FBJ murine osteosarcoma viral oncogene homolog, FBJ murine osteosarcoma viral oncogene homolog B, FBJ osteosarcoma oncogene, FBJ osteosarcoma oncogene B, FBJ osteosarcoma viral oncogene isoform deltaFosb-2, FOS, Fos proto-oncogene, AP-1 trancription factor subunit, Fos proto-oncogene, AP-1 transcription factor subunit, Fosb, FosB proto-oncogene, AP-1 transcription factor subunit, fra-2, G0/G1 switch regulatory protein 7, G0S7, I79_009428, p55, protein fosB, proto-oncogene cFOS, proto-oncogene c-Fos, proto-oncogene protein c-fos, v-fos FBJ murine osteosarcoma viral oncogene homolog
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
2353
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- Specificity: reacts to human Proto-oncogene c-Fos
- It may also react to mouse and rat c-Fos, as predicted by immunogen homology
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- FBJ murine osteosarcoma viral oncogene homolog is commonly known as Cellular protooncogene Fos (c-Fos)
- It belongs to the fos transcription factor family and is encoded by the C-FOS gene located on chromosome 14
- c-Fos heterodimerizes with c-Jun to form the Activator Protein -1 (AP-1) transcription factor which regulates transcription of several genes that play an important role in cellular signal transduction, cell proliferation and differentiation
- c-Fos has been shown to be phosphorylated by various stimuli including growth factors and insulin at atleast seven different sites
- The best known upstream kinase for phosphorylation at Threonine 232 is ERK MAPK which regulates localization of c-Fos to the nucleus and is thus important for c-Fos induced transcriptional activity.