Cytokeratin 5 Recombinant Rabbit Monoclonal Antibody (RM226), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA533066-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA533066 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
Cytokeratin 5
Classification
Recombinant Monoclonal
Concentration
0.04 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.
P13647
Gene Symbols
KRT5
Immunogen
A peptide corresponding to the C-terminus of Human Cytokeratin 5.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
RM226
Conjugate
Unconjugated
Gene
KRT5
Gene Alias
3300001P10Rik, 58 kDa cytokeratin, alpha keratin, AW146334, CK5, CK-5, ckii, ckii protein, cytokeratin 5, cytokeratin-5, DDD, DDD1, EBS2, epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types, K5, keratin 5, keratin 5 (epidermolysis bullosa simplex Dowling-Meara/Kobner/Weber-Cockayne types), keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types), keratin 5, type II, keratin complex 2, basic, gene 5, keratin type II, tail domain, keratin, type II cytoskeletal 5, keratin, type II cytoskeletal 5, keratin 5, keratin-5, Krt2-5, KRT5, KRT5A, Sak57, Tfip8, tuftelin interacting protein 8, type II alpha-keratin IIA, type II cytokeratin, type-II keratin Kb5, wu:fb02h09, wu:fj02d02, wu:fk78b12, zfCKII
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
3852
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- Specificity: reacts to human CK-5 (Cytokeratin 5), and does not cross-react to CK-6 (Cytokeratin 6)
- Specificity: may also react to bovine, mouse, or rat Cytokeratin, as predicted by immunogen homology
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides
- Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8
- The individual human cytokeratins are numbered 1 to 20
- The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium
- Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies
- The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays
- The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state
- Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.