RNASE3 Monoclonal Antibody (5G4), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA534931-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA534931 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
RNASE3
Classification
Monoclonal
Concentration
2 mg/mL
Formulation
PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
P12724
Gene Symbols
RNASE3
Immunogen
Recombinant protein within Human Ribonuclease 3 aa 8-140
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
5G4
Conjugate
Unconjugated
Gene
RNASE3
Gene Alias
cytotoxic ribonuclease; Ear11; EAR-11; Ear3; ECP; Eosinophil cationic protein; eosinophil cationic protein-like; eosinophil cationic-type ribonuclease 3; Eosinophil secondary granule ribonuclease 11; eosinophil-associated ribonuclease 3; eosinophil-associated, ribonuclease A family, member 3; LOC100361866; mR3; MR-3; murine ribonuclease 3; RAF1; Ribonuclease 3; ribonuclease A family member 3; ribonuclease, RNase A family 3; ribonuclease, RNase A family, 3; RNase 3; RNASE3; RNS3
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
6037
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles, store in dark
Form
Liquid
Related Products
Description
- Positive Control: U937, Hela, SHG-44, human spleen tissue, human kidney tissue
- ECP (eosinophil cationic protein), also known as RNS3 or RNASE3 (ribonuclease, RNase A family, 3), is a 160 amino acid potent cytotoxic secretory protein that belongs to the pancreatic ribonuclease family
- ECP localizes to the granule matrix of the eosinophil and is involved in the immune response system
- ECP is a cytotoxin, neurotoxin and helminthotoxin that is secreted by activated human eosinophils
- ECP exhibits anti-parasitic, antibacterial and ribonucleolytic activities
- It has been suggested that ECP induces the neurotoxic effect known as the Gordon phenomenon, a syndrome manifested by ataxia, muscular rigidity, paralysis and tremor that may lead to death
- ECP is considered a marker of eosinophilic inflammation and high levels have been found in cases of active asthma and other allergic diseases.