ALAS1 Recombinant Rabbit Monoclonal Antibody (ARC0239), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA535584-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA535584 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
ALAS1
Classification
Monoclonal
Concentration
0.58 mg/mL
Formulation
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
P13196
Gene Symbols
ALAS1
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 541-640 of human ALAS1 (P13196)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Clone
ARC0239
Conjugate
Unconjugated
Gene
ALAS1
Gene Alias
5'-aminolevulinate synthase 1; 5-aminolevulinate synthase 1; 5-aminolevulinate synthase, nonspecific, mitochondrial; 5-aminolevulinic acid synthase 1; ALAS; ALA-S; ALAS1; Alas-1; ALAS3; ALASH; Alas-h; ALAS-N; aminolevulinate synthase H; aminolevulinate, delta-, synthase 1; aminolevulinic acid synthase 1; delta-ALA synthase 1; delta-ALA synthetase; delta-aminolevulinate synthase 1; MIG4; migration-inducing protein 4; OK/SW-cl.121; succinyl-CoA: glycine C-succinyl transferase
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
211
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
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Description
- Immunogen sequence: TEVCDELMSR HNIYVQAINY PTVPRGEELL RIAPTPHHTP QMMNYFLENL LVTWKQVGLE LKPHSSAECN FCRRPLHFEV MSEREKSYFS GLSKLVSAQA ALAS-1 is a nuclear-encoded mitochondrial matrix enzyme which catalyzes the condensation of glycine with succinyl-CoA to form delta-amino levulinate, CO2 and CoA
- It regulates the first and rate-limiting step of heme biosynthetic pathway
- It is one of the two isoforms of ALAS and is a pyridoxal-5' phosphate dependant housekeeping enzyme
- It is ubiquitously expressed and is responsible of providing heme for cytochromes and other hemoproteins
- ALAS1 in liver undergoes negative feedback regulation by heme
- Transcription of ALAS1 gene is stimulated by cAMP and respiratory uncoupling whereas Phorbol esters and insulin repress ALAS1 gene expression
- ALAS1 is suggested to be involved in reciprocal regulation of Heme biosynthesis and circadian clock suggesting a potential target for treatment of circadian disorders
- ALAS1 gene expression is down regulated in Acute Liver failure resulting in altered heme metabolism and liver function.