Calnexin Recombinant Rabbit Monoclonal Antibody (ARC0648), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA535588-Each-of-1 | In Stock | ₹ 47,837.50 |
PIMA535588 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,837.50
GST (18%): ₹ 8,610.75
Total Price: ₹ 56,448.25
Antigen
Calnexin
Classification
Monoclonal
Concentration
0.55 mg/mL
Formulation
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
P27824
Gene Symbols
CANX
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 493-592 of human Calnexin (P27824)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Western Blot
Clone
ARC0648
Conjugate
Unconjugated
Gene
CANX
Gene Alias
1110069N15Rik; AI988026; calmegin; calnexin; canx; canx-a; canx-b; clgn; clnx; cnx; D11Ertd153e; FLJ26570; hypothetical protein; IP90; Major histocompatibility complex class I antigen-binding protein p88; p88; P90; PP90; pp90 precursor
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
821
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
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Description
- Immunogen sequence: LPVFLVILFC CSGKKQTSGM EYKKTDAPQP DVKEEEEEKE EEKDKGDEEE EGEEKLEEKQ KSDAEEDGGT VSQEEEDRKP KAEEDEILNR SPRNRKPRRE Calnexin, also referred to as IP90, p88 and p90, is an approximately 90 kDa integral membrane protein of the endoplasmic reticulum (ER)
- Many resident ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into multisubunit proteins
- Studies indicate that calnexin associates with the major histocompatibility complex (MHC) class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin, but not with completed receptor complexes
- It has been shown that calnexin is a chaperone that retains incompletely or improperly folded proteins in the ER
- The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble ER resident proteins such as GRP78 and GRP94 and protein disulfide isomerase
- Integral membrane ER resident proteins, like calnexin, often lack this KDEL sequence but contain positively charged cytosolic residues that ensure ER retention
- Calnexin contains a large ER luminal domain (461 amino acids), a transmembrane segment (22 amino acids), and a cytoplasmic tail (89 amino acids).