IL-22 Monoclonal Antibody (C6), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA541620-Each-of-1 | In Stock | ₹ 45,790.50 |
PIMA541620 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,790.50
GST (18%): ₹ 8,242.29
Total Price: ₹ 54,032.79
Antigen
IL-22
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300
Gene Accession No.
Q9GZX6
Gene Symbols
IL22
Immunogen
Recombinant protein Interleukin 22. The antigen corresponds to amino acid range 34-179 of the target protein.
Quantity
200 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2a κ
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
C6
Conjugate
Unconjugated
Gene
IL22
Gene Alias
Cytokine Zcyto18; EGK_03903; il 22; IL-10-related T-cell-derived inducible factor; IL-10-related T-cell-derived-inducible factor; IL-21; IL22; IL-22; Il22a; IL-22a; IL-D110; ILN; ILTIF; IL-TIF; ILTIF alpha; IL-TIF alpha; ILTIFa; Interleukin; interleukin 10-related T cell-derived inducible factor; interleukin 22; Interleukin22; interleukin-22; Interleukin-22a; RGD1561292; TIFa; TIFIL-23; UNQ3099/PRO10096; ZCYTO18
Host Species
Mouse
Purification Method
Protein A/G
Regulatory Status
RUO
Gene ID (Entrez)
50616
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- IL-22 also known as IL-10-related T-cell derived inducible factor, is an alpha helical cytokine and is considered a member of the IFN-IL-10 family, which includes IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and the type I and II interferons
- IL-22 is produced mainly by activated T cells and NK cells
- In humans, the IL-22 gene is located on the q arm of chromosome 12, and is structurally related to IL10
- IL-22 acts by engaging the heterodimeric receptor complex consisting of primary receptor IL-22R1 and accessory receptor IL-10R2
- IL-22R1 also binds IL-20 and IL-24; IL-10R2 also binds IL-10, IL-27, IL-28, and IL-29
- Binding of IL-22 to its receptor complex induces signal transduction, particularly via the JAK-STAT pathway
- In addition to the membrane-bound IL-22R1/IL-10R2 complex, a soluble single-chain IL-22 receptor termed IL-22BP has been found to antagonize IL-22 binding and signaling
- IL-22 appears not to directly influence immune cells, and major targets of the cytokine appear to be nonimmune cells, such as cells of the skin, digestive and respiratory system, as well as hepatocytes, and keratinocytes
- IL-22 has been described as an effector cytokine of the Th17 lineage
- Along with IL-17A and IL-17F, IL-22 regulates genes associated with innate immunity of the skin
- IL-17A, IL-17F and IL-22 are all co-expressed by Th17 cells, however, they are differentially regulated
- The effects of IL-22 include induction of acute phase reactants and antimicrobial proteins, as well as increasing the mobility of keratinocytes
- IL-22 is highly expressed during chronic inflammation, and found to activate intracellular kinases and transcription factors
- IL-22 is critical for host defense against infections of extracellular pathogens, and promotes wound-healing responses
- IL-22 is upregulated in activated T cells
- IL-22 has been reported to mediate IL-23-induced acanthosis and dermal inflammation through activation of STAT3.