DKK1 Monoclonal Antibody (C5), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA543857-Each-of-1 | In Stock | ₹ 17,702.10 |
PIMA543857 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 17,702.10
GST (18%): ₹ 3,186.378
Total Price: ₹ 20,888.478
Antigen
DKK1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300
Gene Accession No.
O94907
Gene Symbols
DKK1
Immunogen
Recombinant protein Dickkopf Related Protein 1. The antigen corresponds to amino acid range 33-266 of the target protein.
Quantity
20 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2b κ
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
C5
Conjugate
Unconjugated
Gene
DKK1
Gene Alias
dickkopf 1 homolog; dickkopf homolog 1; dickkopf homolog 1 (Xenopus laevis); dickkopf related protein-1; dickkopf WNT signaling pathway inhibitor 1; Dickkopf1; dickkopf-1; dickkopf-1 like; dickkopf-like protein 1; dickkopf-related protein 1; DKK1; DKK-1; hDkk1; hDkk-1; mdkk-1; SK; UNQ492/PRO1008
Host Species
Mouse
Purification Method
Protein A/G
Regulatory Status
RUO
Gene ID (Entrez)
22943
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4
- DKK-1 was originally identified as a Xenopus head-forming molecule that behaves as an antagonist for Wnt signaling
- Subsequent studies have shown that DKK-1 and DKK-4 play important regulatory roles in the Wnt/beta-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/beta-catenin signaling system
- LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/beta-catenin signaling cascade
- It has been suggested that by inhibiting Wnt/beta-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development
- This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis.