CD2 Monoclonal Antibody (RM2-5), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA544026-Each-of-1 | In Stock | ₹ 23,629.50 |
PIMA544026 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 23,629.50
GST (18%): ₹ 4,253.31
Total Price: ₹ 27,882.81
Antigen
CD2
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 15mM sodium azide; pH 7.4
Gene Accession No.
P08920
Gene Symbols
CD2
Immunogen
murine thymocytes
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2b λ
Applications
Flow Cytometry, Immunoprecipitation
Clone
RM2-5
Conjugate
Unconjugated
Gene
CD2
Gene Alias
Cd2; CD2 antigen; CD2 antigen (p50), sheep red blood cell receptor; CD2 molecule; CD2R; cluster of differentiation 2; Erythrocyte receptor; FLJ46032; LFA2; LFA-2; LFA-3 receptor; Ly37; Ly-37; lymphocyte antigen 37; OX34; OX-34; OX-34 antigen; OX-45 surface antigen homolog to human T lymphocyte CD2 antigen; Rosette receptor; SRBC; surface immunoglobulin superfamily molecule; T11; T-cell surface antigen CD2; T-cell surface antigen T11/Leu-5
Host Species
Rat
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
12481
Content And Storage
4° C, do not freeze
Form
Liquid
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Description
- CD2 (LFA-2) is a monomeric surface antigen (MW range 45-58 kDa) of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells
- CD2 is one of the earliest T-cell markers, being present on more than 95% of thymocytes and it is also found on some natural killer cells, but not on B lymphocytes
- Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it
- The interaction between CD2 and CD58 stabilizes adhesion between T cells and antigen presenting or target cells
- Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion
- Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58
- Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion
- CD2 deficiency reduces intestinal inflammation and helps to control infection
- Diseases associated with CD2 dysfunction include penis squamous cell carcinoma and immune deficiency due to the absence of the thymus.