B7-H4 Recombinant Rabbit Monoclonal Antibody (BLR043F), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA544281-Each-of-1 | In Stock | ₹ 42,364.00 |
PIMA544281 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,364.00
GST (18%): ₹ 7,625.52
Total Price: ₹ 49,989.52
Antigen
B7-H4
Classification
Recombinant Monoclonal
Concentration
50 μg/mL
Formulation
BBS with 0.1% BSA and 0.09% sodium azide; pH 7.8-8.6
Gene Accession No.
Q7Z7D3
Gene Symbols
Vtcn1
Immunogen
Residues 30-282 (Ecd)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
BLR043F
Conjugate
Unconjugated
Gene
Vtcn1
Gene Alias
B7 family member, H4; B7 homolog 4; B7 superfamily member 1; B7h.5; B7H4; B7-H4; B7s1; B7x; BC032925; EMBL:AAH95842.1}; FLJ22418; immune costimulatory protein B7-H4; PRO1291; Protein B7S1; RGD1311204; RP11-229A19.4; t cell costimulatory molecule B7x; T-cell costimulatory molecule B7x; UNQ659/PRO1291; VCTN1; V-set domain containing T cell activation inhibitor 1; V-set domain containing T-cell activation inhibitor 1; V-set domain-containing T-cell activation inhibitor 1; Vtcn1; vtcn1 {ECO:0000312
Host Species
Rabbit
Purification Method
purified
Regulatory Status
RUO
Gene ID (Entrez)
79679
Content And Storage
2-8°C
Form
Liquid
Related Products
Description
- Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections
- B7-H4 (B7x, VTCN1) a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity
- Although B7-H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production
- B7-H4 deficient mice are only minimally affected; suggesting B7-H4 is important in the fine tuning of the T-cell mediated immune response
- B7-H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells
- Aberrant expression has been associated with cancers of the lung, breast and ovary in humans
- B7-H4 is expressed primarily on the membrane of lymphoid cells, and as an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, it is involved in mediating cellular and humoral immune responses
- Overexpression of B7-H4 is associated with certain malignancies, including ovarian and breast cancer, which may be a mechanism by which tumor cells suppress T cell immunity and facilitate tumor progression
- Further, VTCN1 may be a useful biomarker for the early detection of ovarian cancer and Renal Cell Carcinoma (RCC).