PIMA544302
CD73 Recombinant Rabbit Monoclonal Antibody (BLR054F), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA544302-Each-of-1 | In Stock | ₹ 14,035.30 |
PIMA544302 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 14,035.30
GST (18%): ₹ 2,526.354
Total Price: ₹ 16,561.654
Antigen
CD73
Classification
Recombinant Monoclonal
Concentration
100 μg/mL
Formulation
BBS with 0.1% BSA and 0.09% sodium azide, pH 8.2
Gene Accession No.
P21589
Gene Symbols
NT5E
Immunogen
Residues 27-552 (Ecd)
Quantity
10 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
BLR054F
Conjugate
Unconjugated
Gene
NT5E
Gene Alias
2210401F01Rik; 5 nucleotidase, ecto; 5' nucleotidase, ecto; 5'-NT; 5'-nucleotidase; 5'-nucleotidase ecto; 5'-nucleotidase, ecto (CD73); AI447961; CALJA; CD73; E5NT; ecto-5'-nucleotidase; eN; eNT; NT; Nt5; Nt5e; NTE; Purine 5-Prime-Nucleotidase
Host Species
Rabbit
Purification Method
purified
Regulatory Status
RUO
Gene ID (Entrez)
4907
Content And Storage
2-8°C
Form
Liquid
Related Products
Description
- Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections
- CD73 (Ecto-5-prime-nucleotidase, 5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP
- CD73 consists of a dimer of 2 identical 70 kDa subunits bound externally to the plasma membrane by a glycosyl phosphatidyl inositol linkage
- CD73 is used as a marker of lymphocyte differentiation
- Consequently, a deficiency of CD73 occurs in a variety of immunodeficiency diseases
- Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from CD73 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate
- The CD73 gene has been localized to 6q14-q21 by immunofluorescence and a study of a panel of human x mouse hybrids that contained fragments of chromosome 6 as translocations
- Defects in the CD73 gene can lead to the calcification of joints and arteries, and intestinal tuberculosis
- Two transcript variants encoding different isoforms of CD73 have been found.