MERTK Recombinant Rabbit Monoclonal Antibody (RM469), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA544594-Each-of-1 | In Stock | ₹ 39,961.00 |
PIMA544594 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 39,961.00
GST (18%): ₹ 7,192.98
Total Price: ₹ 47,153.98
Antigen
MERTK
Classification
Recombinant Monoclonal
Concentration
50 μg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.
Q60805
Gene Symbols
Mertk
Immunogen
Recombinant protein of MerTK extracellular domain. Sequence is proprietary.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Mouse
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
RM469
Conjugate
Unconjugated
Gene
Mertk
Gene Alias
c-Eyk, c-mer, c-mer proto-oncogene tyrosine kinase, Eyk, MER, MER proto-oncogene, tyrosine kinase, MER receptor tyrosine kinase, MERTK, MGC133349, nmf12, Nyk, Proto-oncogene c-Mer, proto-oncogene tyrosine-protein kinase MER, rdy, receptor tyrosine kinase MerTK, Receptor tyrosine tinase gene probably the gene for Rdy, retinal dystrophy, RP38, sMER, sMERTK, soluble MER, soluble MERTK, STK kinase, Tyro 12, Tyro12, Tyrosine-protein kinase Mer
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
17289
Content And Storage
-20°C
Isotype
IgG
Related Products
Description
- MERTK (cMER) is a tyrosine kinase proto-oncogene and is involved in the retinal pigment epithelium (RPE) phagocytosis pathway, which is implicated in human retinal disease
- Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis)
- Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules
- Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1
- MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment
- Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis
- Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.