ATP7A Monoclonal Antibody (S60-4), FITC, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA545519-Each-of-1 | In Stock | ₹ 40,317.00 |
PIMA545519 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,317.00
GST (18%): ₹ 7,257.06
Total Price: ₹ 47,574.06
Antigen
ATP7A
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
9.1mM sodium bicarbonate, 9.44mM PBS with 123mM ethanolamine, 581mM DMSO and no preservative; pH 7.4
Gene Accession No.
P70705, Q04656, Q64430
Gene Symbols
ATP7A
Immunogen
Synthetic peptide amino acids 42-61 (cytoplasmic C-terminus) of human Copper- transporting ATPase1
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Clone
S60-4
Conjugate
FITC
Gene
ATP7A
Gene Alias
ATP 7A; ATP7A; ATPase copper transporting alpha; ATPase, Cu++ transporting, alpha polypeptide; copper pump 1; Copper-transporting ATPase 1; Cu++-transporting P-type ATPase; DSMAX; FLJ17790; MC 1; MC1; Menke; Menkes disease-associated protein; menkes disease-associated protein homolog; Menkes protein; Menkes syndrome; MK; MNK; OHS; OTTHUMP00000062077; SMAX3
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
11977, 24941, 538
Content And Storage
4° C, store in dark
Isotype
IgG2b
Related Products
Description
- 1 μg/mL of MA5-45519 was sufficient for detection of Copper-transporting ATPase1 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat IgG:HRP as the secondary antibody.∣Detects approximately 180kDa in rat brain membrane preparations
- ATP7A (also known as Copper-transporting ATPase 1) functions as a transmembrane copper-translocating P-type ATPase and plays a vital role in systemic copper absorption in the gut and copper reabsorption in the kidney
- Polarized epithelial cells such as Madin-Darby canine kidney cells are a physiologically relevant model for systemic copper absorption and reabsorption in vivo
- Although ATP7A is not detectable in most normal tissues, it is expressed in a considerable fraction of many common tumor types
- Increased expression of ATP7A renders cells resistant to cisplatin and carboplatin
- Mutations in the ATP7A gene result in Menkes disease, which is fatal in early childhood.