PIMA546748
CD33 Recombinant Rabbit Monoclonal Antibody (001), FITC, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA546748-Each-of-1 | In Stock | ₹ 38,181.00 |
PIMA546748 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,181.00
GST (18%): ₹ 6,872.58
Total Price: ₹ 45,053.58
Antigen
CD33
Classification
Recombinant Monoclonal
Concentration
100 μg/mL
Formulation
PBS with 0.5% BSA and 0.09% sodium azide
Gene Accession No.
P20138
Gene Symbols
CD33
Immunogen
Recombinant protein ecoding Human CD33 (Met1-His259).
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry
Clone
001
Conjugate
FITC
Gene
CD33
Gene Alias
CD33; CD33 antigen; CD33 antigen (gp67); CD33 molecule; CD33 molecule transcript; FLJ00391; gp67; Myeloid cell surface antigen CD33; p67; sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3; SIGLEC3; Siglec-3
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
945
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Related Products
Description
- Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Human CD33 (Met1-His259) and conjugated with FITC under optimum conditions, the unreacted FITC was removed
- Storage: This antibody can be stored at 2C-8C for twelve months without detectable loss of activity
- Protected from prolonged exposure to light
- Do not freeze! Sodium azide is toxic to cells and should be disposed of properly
- Flush with large volumes of water during disposal
- CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family
- It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies, and these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface
- CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia
- Further, CD33 is found on granulocyte and macrophage precursors in the bone marrow, but is not on pluripotent stem cells
- CD33 is also expressed on, and is a useful marker for, peripheral monocytes
- CD33 is useful for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias
- Diseases associated with CD43 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.