GRK2 Recombinant Rabbit Monoclonal Antibody (HL1562), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA547096-Each-of-1 | In Stock | ₹ 40,317.00 |
PIMA547096 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,317.00
GST (18%): ₹ 7,257.06
Total Price: ₹ 47,574.06
Antigen
GRK2
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative
Gene Accession No.
P25098, P26817, Q99MK8
Gene Symbols
GRK2
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human GRK2. The exact sequence is proprietary.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
HL1562
Conjugate
Unconjugated
Gene
GRK2
Gene Alias
ADRBK1; Adrbk-1; adrenergic beta receptor kinase 1; adrenergic receptor kinase, beta 1; adrenergic, beta, receptor kinase 1; BARK; BARK1; Bark-1; beta ARK; Beta-adrenergic receptor kinase 1; beta-adrenergic receptor kinase 1 beta ARK1; beta-AR kinase-1; betaARK1; BETA-ARK1; beta-ARK-1; EC 2.7.1.126; G protein-coupled receptor kinase 2; G-protein coupled receptor kinase 2; G-protein-coupled receptor kinase 2; grk 2; Grk2; GRK-2
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
110355, 156, 25238
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Store as concentrated solution
- Centrifuge briefly prior to opening vial
- ADRBK1 (GRK2) is a serine/threonine kinase
- Many of the G protein-coupled receptors are known to be phosphorylated by G protein-dependent receptor kinases (GRKs)
- G protein-coupled receptor kinases (GRKs) are important regulators of G protein-coupled receptors(GPCRs)
- GRK2 (83 kDa), one of six members of this family that have been identified, is ubiquitously expressed in mammals
- After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs (e.g., a2-adrenergic receptor) are phosphorylated by GRKs
- Internalization of the GPCRs, regulated by beta-arrestin-1, leads to activation of the Ras - Raf - ERK1&2 signaling pathway
- GRK2 activity is tightly controlled by different mechanisms including phosphorylation by kinases such as PKC, Src and ERK1&2, as well as interaction with various proteins
- ERK phosphorylates and thus inactivates GRK2 on serine 670 in a negative feedback mechanism.