PIMA547659
CD244 (2B4) Monoclonal Antibody (M053), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA547659-Each-of-1 | In Stock | ₹ 47,659.50 |
PIMA547659 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,659.50
GST (18%): ₹ 8,578.71
Total Price: ₹ 56,238.21
Antigen
CD244 (2B4)
Classification
Monoclonal
Concentration
Lot-Specific
Formulation
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.
Q9BZW8
Gene Symbols
CD244
Immunogen
Clone (M053) was generated from a recombinant protein that included the extracellular region of human CD244 protein.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot
Clone
M053
Conjugate
Unconjugated
Gene
CD244
Gene Alias
NKR2B4; SLAMF4
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
51744
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG1
Related Products
Description
- Clone M053 mouse monoclonal antibody detects a 110 kDa* protein on SDS-PAGE Native or denatured immunoblots of human THP1 monocytes
- The antibody prefers the native CD244 protein, but also detects denatured CD244
- The antibody works for western blot, immunoprecipitation, immunocytochemistry, and ELISA capture
- CD244 (Natural killer (NK) cell receptor 2B4/SLAMF4) is an Ig superfamily signaling lymphocyte activation molecule (SLAM) receptor
- Like all SLAM family receptors, it has an extracellular segment with two immunoglobulin (Ig)-like domains, and a cytoplasmic domain containing four immunoreceptor tyrosine-based switch motifs
- CD244 does not act as a selfligand similar to other SLAM family receptors
- It binds CD48, a transmembrane receptor ubiquitously expressed on hematopoietic cells
- CD244 activity is controlled by the presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2
- Downstream signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL
- Activation of CD244 stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis
- CD244 is involved in the regulation of CD8+ T-cell proliferation, and inhibits inflammatory responses in dendritic cells (DCs)
- In cancers, CD244 shows increased expression in intratumoral DCs and myeloid suppressor cells, and anti-CD244 therapies may increase infiltrating T-cells and impair tumor growth.