INSR alpha Chimeric Recombinant Rabbit Monoclonal Antibody (83-7), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA547793-Each-of-1 | In Stock | ₹ 46,769.50 |
PIMA547793 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,769.50
GST (18%): ₹ 8,418.51
Total Price: ₹ 55,188.01
Antigen
INSR alpha Chimeric
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.02% ProClin 300
Gene Accession No.
P06213
Gene Symbols
INSR
Immunogen
Epitope within amino acids 140-301 (the cysteine rich region) of the extracellular domain of the human Insulin Receptor alpha.
Quantity
200 μg
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation
Clone
83-7
Conjugate
Unconjugated
Gene
INSR
Gene Alias
4932439J01Rik; CD220; CD220 beta; D630014A15Rik; DAF-2; HHF5; INSR; insulin receptor; insulin receptor (INSR); insulin receptor precursor; insulin receptor preproprotein; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR alpha; IR beta; ir-A; IR-B
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3643
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG κ
Related Products
Description
- Specificity: Recognises the extracellular domain of the Insulin Receptor alpha
- Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades
- The insulin receptor
- Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins
- These two receptors differ in sequence in regions that confer specificity for the designated ligand as well as in certain intracellular signaling domains, resulting in significant differences in the functional consequences of activation of each receptor
- Defects in IR are the cause of various insulin resistance syndromes and IGF-1R defects may cause some forms of growth retardation
- Both these signaling cascades are also important for the development of cancer.