PIMA547836
Basiliximab Chimeric Recombinant Rabbit Monoclonal Antibody (Basiliximab), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA547836-Each-of-1 | In Stock | ₹ 46,769.50 |
PIMA547836 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,769.50
GST (18%): ₹ 8,418.51
Total Price: ₹ 55,188.01
Antigen
Basiliximab Chimeric
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.02% ProClin 300
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Target Species
Cynomolgus Monkey, Human, Rhesus Monkey
Form
Liquid
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Inhibition Assays, Western Blot
Clone
Basiliximab
Conjugate
Unconjugated
Gene Alias
CHI621
Immunogen
Basiliximab was prepared by immunizing BALB/c mice with CTC 16 cells.
Quantity
200 μg
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG κ
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Description
- Specificity: Basiliximab recognises the human IL-2R and binds to the epitope (116)ERIYHFV(122) within the extracellular domain of the CD25 subunit-binding is abolished when 2 or more residues within the epitope are mutated
- This epitope overlaps with the interaction site of CD25 and IL-2
- CD25 is found in the high-affinity IL-2R (alpha-Beta-gamma-c)-T cells only express CD25 upon activation
- IL-2 binding to IL-2R on T cells modulates proliferation and differentiation
- A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes
- It is a 144 kDa glycoprotein obtained from fermentation of an established mouse myeloma cell line genetically engineered to express plasmids containing the human heavy and light chain constant region genes and mouse heavy and light chain variable region genes encoding the RFT5 antibody that binds selectively to the IL-2R alpha
- Basiliximab binds with high-affinity to the alpha-subunit (CD25) of the high-affinity IL-2 receptor
- This inhibits IL-2 binding, which inhibits T-cell activation and prevents the body from mounting an immune response against the foreign kidney.