CD86 Chimeric Recombinant Rabbit Monoclonal Antibody (PO.3), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA548134-Each-of-1 | In Stock | ₹ 46,769.50 |
PIMA548134 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,769.50
GST (18%): ₹ 8,418.51
Total Price: ₹ 55,188.01
Antigen
CD86 Chimeric
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.02% ProClin 300
Gene Accession No.
P42082
Gene Symbols
CD86
Immunogen
This antibody was raised by immunising Sprague Dawley rats with a mouse B cell line, BCL1 and fusing immune splenocytes with P3U1 myeloma cells.
Quantity
200 μg
Primary or Secondary
Primary
Target Species
Mouse
Form
Liquid
Applications
Flow Cytometry, Functional Assay, Immunocytochemistry, Immunohistochemistry, Inhibition Assays
Clone
PO.3
Conjugate
Unconjugated
Gene
CD86
Gene Alias
activation B7-2 antigen; B lymphocyte activation antigen B72; B7; B7.2; B70; B7-2; B-lymphocyte activation antigen B7-2; BU63; CD28 antigen ligand 2; Cd28l2; CD28LG2; CD86; CD86 antigen; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); CD86 antigen precursor; CD86 molecule; CLS1; CTLA-4 counter-receptor B7.2; early T cell costimulatory molecule-1; early T-cell costimulatory molecule 1; Early T-cell co-stimulatory molecule 1; ETC-1; FUN-1; LAB72; Ly58; Ly-58; MB7; MB7-2; membrane glycoprotein; MGC34413; T-lymphocyte activation antigen CD86; TS/A-2
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12524
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG κ
Related Products
Description
- Specificity: This antibody is specific for murine CD86, an ∽80 kDa surface receptor of the B7 family of costimulatory molecules
- In addition to CD80, CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4)
- This interaction plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production and Th2-mediated Ig production
- CD86 is one of two ligands (the other CD80) for CTLA4 and CD28
- CD86 acts as costimulatory molecule in eliciting T-cell help during antigen presentation
- Antigen presentation in the absence of sufficient co-stimulation involving CD86/CD80 can induce tolerance
- CD80 appears to play a role distinct from CD80 in T helper cell differentiation
- CD86 is a type I membrane protein that is a member of the immunoglobulin superfamily
- The CD86 protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4
- Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell
- Binding of CD86 with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response
- Alternative splicing results in two transcript variants encoding different isoforms of CD86
- Additional transcript variants have been described for CD86, but their full-length sequences have not been determined
- Diseases associated with CD86 dysfunction include gallbladder squamous cell carcinoma and myocarditis.