CCRL2 Chimeric Recombinant Rabbit Monoclonal Antibody (BZ5B8), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA548141-Each-of-1 | In Stock | ₹ 46,769.50 |
PIMA548141 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,769.50
GST (18%): ₹ 8,418.51
Total Price: ₹ 55,188.01
Antigen
CCRL2 Chimeric
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.02% ProClin 300
Gene Accession No.
O35457
Gene Symbols
CCRL2
Immunogen
This antibody was raised by immunising Wistar Furth rats with the mCCRL2 peptide (aa 1-24) /KLH conjugate.
Quantity
200 μg
Primary or Secondary
Primary
Target Species
Mouse
Form
Liquid
Applications
ELISA, Flow Cytometry, Functional Assay, Immunocytochemistry, Immunohistochemistry
Clone
BZ5B8
Conjugate
Unconjugated
Gene
CCRL2
Gene Alias
1810047I05Rik; Ackr5; atypical chemokine receptor 5; C-C chemokine receptor-like 2; C-C motif chemokine receptor like 2; CCR11; CCR6; Ccrl2; chemokine (C-C motif) receptor-like 2; chemokine C-C motif receptor-like 2; chemokine C-C motif receptor-like 2-like; chemokine receptor CCR11; Chemokine receptor X; CKRX; Cmkbr1l2; CRAM; CRAM-A; CRAM-B; E01; G-protein coupled beta chemokine receptor; HCR; Lccr; L-CCR; Lipopolysaccharide-inducible C-C chemokine receptor; LOC100719164; MGC116710; Putative MCP-1 chemokine receptor
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
54199
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG κ
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Description
- Specificity: This antibody is specific for murine CCRL2 (formerly known as L-CCR), which is expressed on mast cells, activated macrophages, and endothelial cells
- This receptor binds the leukocyte chemoattractant chemerin without triggering classical GPCR signaling, providing a specific mechanism for local enrichment of chemerin at inflammatory sites
- CCRL2 presents active chemerin to leukocytes expressing the chemoattractant receptor CMKLR1/Chemr23
- Chemerin can block anti-CCRL2 antibody binding
- Preparation: This antibody was raised by immunising Wistar Furth rats with the mCCRL2 peptide/KLH conjugate
- The immunizing amino-terminal mCCRL2 peptide with the sequence NH2-MDNYTVAPDDEYDVLILDDYLDNSC-COOH, corresponding to residues 1-24 of mCCRL2, with a nonnative carboxyl-terminal cysteine to facilitate conjugation to keyhole limpet hemocyanin (KLH)
- CCRL2 (C-C chemokine receptor-like 2), also known as chemokine receptor X, human chemokine receptor (HCR), CRAM-A or CRAM-B, is a seven pass transmembrane protein expressed by monocytes, neutrophils, and dendritic cells of immunal tissues (predominanly spleen, fetal liver, bone marrow and lymph node)
- It shares over 40% homology with other C-C chemokine receptors but does not share the conserved DRY motif which is among the important motifs necessary for signalling and ligand-binding
- C-C chemokine receptors are G-protein coupled, seven pass transmembrane domain proteins whose major physiological role is to function in the chemotaxis of T cells and phagocytic cells to areas of inflammation.