PIMA549585
Endostatin Monoclonal Antibody (KT60), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA549585-Each-of-1 | In Stock | ₹ 47,659.50 |
PIMA549585 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,659.50
GST (18%): ₹ 8,578.71
Total Price: ₹ 56,238.21
Antigen
Endostatin
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
P39060
Gene Symbols
COL18A1
Immunogen
Recombinant Human COL18A1
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA
Clone
KT60
Conjugate
Unconjugated
Gene
COL18A1
Gene Alias
antiangiogenic agent, Col18a1, Collagen alpha-1(XVIII) chain, collagen type XVIII alpha 1 chain, collagen, type XVIII, alpha 1, endostatin, FLJ27325, FLJ34914, KNO, KNO1, KS, MGC74745, multi-functional protein MFP, NC1, Non-collagenous domain 1, procollagen, type XVIII, alpha 1
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
80781
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG2a
Related Products
Description
- This product was used in both Indirect and Sandwich ELISA
- Endostatin is able to avoke non-uniform response for proliferation, cell mount and migration of entothelial cells, which different endostatin binding characteristic, leads to the assumption that endostatin effect is strongly dependent from endothelial cell type
- Furthermore endostatin inhibits angiogenesis and tumor growth in vivo by inducing apoptosis in endothelial cells
- The local delivery of endostatin seems to specifically affect tumor-associated microvessels by reduction of the vessel density, diameter and functionality
- Tumor cell migration and invasion was greatly reduced in the endostatin treated animals
- Endostatin is non-toxic and does not induce aquired drug resistance and has therefor become a potent new therapy strategy in solid neoplasias
- This therapy appears to have a high potential not only for the treatment of gliomas, the most common brain tumors, but also in other tumors
- The ability of endostatin to inhibit neoangiogenesis is mediated, at least in part, by Zn^+2 binding and elastase processing
- Widespread endostatin expression was found in elactic fibers in vessel walls and in some other basement membrane zones
- Endostatin is released by neurons to accumulate in amyloid plaques in Alzheimer's disease.