Caffeine Monoclonal Antibody (F1-P2B1G1), Invitrogen™

Description

• MIC0401 targets Caffeine in ELISA, and RIA applications and shows reactivity with Chemical samples
• The MIC0401 immunogen is caffeine-3-KLH
• MIC0401 was formerly sold as a Seradyn product
• Caffeine is a methylxanthine alkaloid found in the seeds, nuts, or leaves of a number of plants native to South America and East Asia that is structurally related to adenosine and acts primarily as an adenosine receptor antagonist with psychotropic and anti-inflammatory activities
• Upon ingestion, caffeine binds to adenosine receptors in the central nervous system (CNS), which inhibits adenosine binding
• This inhibits the adenosine-mediated downregulation of CNS activity; thus, stimulating the activity of the medullary, vagal, vasomotor, and respiratory centers in the brain
• This agent also promotes neurotransmitter release that further stimulates the CNS
• The anti-inflammatory effects of caffeine are due the nonselective competitive inhibition of phosphodiesterases (PDEs)
• Inhibition of PDEs raises the intracellular concentration of cyclic AMP (cAMP), activates protein kinase A, and inhibits leukotriene synthesis, which leads to reduced inflammation and innate immunity
• [National Center for Biotechnology Information
• PubChem Compound Database; CID=2519].