Fibronectin Monoclonal Antibody (3F12), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMIF2601-Each-of-1 | In Stock | ₹ 72,357.00 |
PIMIF2601 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 72,357.00
GST (18%): ₹ 13,024.26
Total Price: ₹ 85,381.26
Antigen
Fibronectin
Classification
Monoclonal
Concentration
5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.4
Gene Accession No.
P02751
Gene Symbols
FN1
Immunogen
Human plasma fibonectin
Quantity
1 mg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
ELISA, Immunocytochemistry, Immunoprecipitation, Radioimmune Assays (RIA), Western Blot
Clone
3F12
Conjugate
Unconjugated
Gene
FN1
Gene Alias
Anastellin; CIG; Cold insoluble globulin (CIG); Cold-insoluble globulin; cumulus cell-specific fibronectin 1 transcript; DKFZp686F10164; DKFZp686H0342; DKFZp686I1370; DKFZp686O13149; E330027I09; ED-B; embryo-specific fibronectin 1 transcript; ferritin L subunit; ferritin L-chain; FIBNEC; fibronectin; fibronectin 1; fibronectin ED-A- region; fibronectin ED-B+ region; fibronectin variable region; FINC; FN; FN1; fn-1; FNZ; GFND; GFND2; LETS; LOW QUALITY PROTEIN: fibronectin; Migration stimulating factor (MSF); migration-stimulating factor; MSF; Ugl-Y1; Ugl-Y2; Ugl-Y3
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
2335
Content And Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C
Form
Liquid
Related Products
Description
- MIF2601 has been successfully used in WB, ELISA, immunofluorescence, immunoprecipitation, and radioimmune assay applications, and reacts with human samples
- MIF2601 detects Fibronectin which has a predicted molecular weight of approximately 259 kDa
- MIF2601 was formerly sold as a Seradyn product
- Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230-250 kDa
- In the extracellular matrix of several connective tissues and vessels, fibronectin is present as an insoluble protein that is extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers
- Fibronectin is most abundant during embryonic development and tissue remodeling
- Fibronectin is also present at high concentrations as a soluble plasma protein
- Fibronectin is organized as a linear series of repeating modules which form domains for interaction with fibronectin itself, other matrix components (e.g
- collagen and heparin) and receptors on cells (e.g
- integrins)
- Fibronectin is present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix
- Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis
- Fibronectin has been implicated in carcinoma development in lung cancer
- Further, Fibronectin expression is increased especially in non-small cell lung carcinoma
- The adhesion of lung carcinoma cells to Fibronectin enhances tumorgenecity and confers resistance to apoptosis induced by standard chemotherapeutic agents
- The gene encoding Fibronectin has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants
- However, the full-length nature of some Fibronectin variants has not been determined.