PIOSN00002A
NGF Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIOSN00002A-Each-of-1 | In Stock | ₹ 42,720.00 |
PIOSN00002A - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,720.00
GST (18%): ₹ 7,689.60
Total Price: ₹ 50,409.60
Antigen
NGF
Classification
Polyclonal
Gene
NGF
Gene Alias
beta-nerve growth factor, NGFB, beta-NGF
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
18049, 310738, 4803
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Lyophilized
Applications
Immunohistochemistry, In vitro Assay, Inhibition Assays, Western Blot
Conjugate
Unconjugated
Gene Accession No.
P01138, P01139, P25427
Gene Symbols
NGF
Immunogen
Native beta-nerve growth factor
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Tested in vitro, this antibody abolishes the neuronal survival and the outgrowth actions of murine NGF in chicken DRG
- Reconstitute in 100 μl sterile water
- Centrifuge to remove insoluble material
- Use at a concentration of 1-5 μg/mL
- Nerve growth factor (NGF) influences the survival and differentiation of a variety of neuronal and nonneuronal cells
- The actions of this polypeptide result from binding to specific cell surface receptors which are present as both high and low affinity sites
- Although both types of receptor bind NGF only the high affinity form is capable of signal transduction
- Cross-linking studies with 125I-NGF have shown that the high affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF while the low affinity receptor forms an Mr 100,000 complex
- Full length cDNA clones for both the human and rat NGF receptor genes have been produced and sequenced, revealing greater than 90% homology between the two species
- NGF exhibits nerve growth stimulating activity and is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons
- Further, NGF stimulates division and differentiation of sympathetic and embryonic sensory neurons
- Mutations in the NGF gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of NGF gene expression is associated with allergic rhinitis.