MDMX Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA127958-Each-of-1 | In Stock | ₹ 54,824.00 |
PIPA127958 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 54,824.00
GST (18%): ₹ 9,868.32
Total Price: ₹ 64,692.32
Antigen
MDMX
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MDM4
Gene Alias
4933417N07Rik; AA414968; AL023055; AU018793; AU021806; C85810; DKFZp781B1423; double minute 4 homolog; double minute 4 protein; double minute 4, human homolog of; p53-binding protein; HDMX; human homolog of; Mdm2-like p53-binding protein; MDM4; Mdm4 p53 binding protein homolog; MDM4 protein variant G; MDM4 protein variant Y; MDM4, p53 regulator; MDM4-related protein 1; Mdmx; MGC132766; MRP1; p53-binding protein Mdm4; Protein Mdm4; protein Mdmx; RP11-430C7.1; transformed mouse 3T3 cell double minute 4
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
4194
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Western Blot
Concentration
0.5 mg/mL
Formulation
PBS with 2% sucrose and 0.09% sodium azide
Gene Accession No.
O15151
Gene Symbols
MDM4
Immunogen
A synthetic peptide corresponding to a N-terminal region of Human MDM4
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: HepG2, MCF-7
- Predicted reactivity: Cow: 80%; Dog: 93%; Horse: 93%; Pig: 86%; Rabbit: 80%
- Use at a concentration of 1 μg/mL in 5% skim milk/PBS buffer
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- The MDM2 protein is the primary regulator of p53 protein stability
- MDMX is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 via distinct associations with MDM2
- The gene that encodes MDMX (also designated MDM4) is a target for amplification in malignant gliomas
- ARF interacts with MDMX to sequester MDMX within the nucleolus
- This sequestration of MDMX by ARF results in an increase in p53 transactivation
- In addition, expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation
- Like MDM2, MDMX also binds p73 and stabilizes the level of p73
- Therefore, in striking contrast to p53, the half-life of p73 is increased by binding to MDM2.