CNTF Polyclonal Antibody, Invitrogen™

Description

• Reconstitute with 0.1 mL of distilled water
• Prior to reconstitution, store at 4oC
• After reconstitution, store undiluted at -20oC, avoiding freeze/thaw cycles
• This antibody may be used in Western Blotting applications under either reducing or non-reducing conditions
• Rabbit anti Human CTNF antibody recognizes human CNTF (ciliary neurotrophic factor), a 200 amino acid homodimeric neurotrophic and differentiation factor of the CNTF family, which supports the survival and differentiation of several motor neuron types within the nervous system, but also affects other target tissues, including skeletal muscle (Vergara & Ramirez 2005), glial cells, hepatocytes and embryonic stem cells
• The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations
• The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks
• A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease
• A read-through transcript variant composed of ZFP91 and CNTF sequence has been identified, but it is thought to be non-coding
• Read-through transcription of ZFP91 and CNTF has also been observed in mouse.