Aurora B Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA186828-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA186828 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
Aurora B
Classification
Polyclonal
Conjugate
Unconjugated
Gene
AURKB
Gene Alias
Aik2; AIM1; AIM-1; AIRK2; AL022959; ARK2; ARK-2; AurB; AURKB; aurkb-sv1; aurkb-sv2; aurora 1; aurora- and IPL1-like midbody-associated protein 1; aurora B; aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora/IPL1-related kinase 2; aurora-1; aurora-B; aurora-related kinase 2; IPL1; PPP1R48; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase; serine/threonine kinase 12; serine/threonine kinase 5; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; serine/threonine-protein kinase aurora-B; STK1; STK-1; Stk12; STK12; AIK2; AIM1; ARK2; IPL1; AIM-1; STK5
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
114592, 20877, 360192, 396955, 479492, 9212
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
ELISA, Western Blot
Concentration
0.2 mg/mL
Formulation
PBS with <0.1% sodium azide; pH 7.2
Gene Accession No.
O55099, O70126, Q7YRC6, Q96GD4, Q9N0X0
Gene Symbols
AURKB
Immunogen
Synthetic peptide corresponding to amino acids 227-238 of human Aurora-B kinase
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Bovine, Canine, Human, Mouse, Non-human Primate, Porcine, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Predicted to react with bovine, chimpanzee, dog, mouse, pig and rat based on sequence homology
- In Western blot, this antibody detects a band at ∽39kDa in HeLa cell lysate
- Rabbit anti Human Aurora-B kinase antibody detects human Aurora-B kinase (AurB), a serine/threonine kinase which is the enzymatic core of the Chromosomal Passenger Complex (CPC)
- The Aurora kinases associate with microtubules during chromosome movement and segregation
- AURKB (Aurora B) localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers
- This complex functions in chromosome alignment and separation, histone modification, and cytokinesis
- CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin, and borealin, which determine the activity, localization, stability, and possibly even the substrate specificity of AurB
- Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and AurB
- Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-AurB complex may be responsible for modifying histone H3
- AurB is overexpressed in a number of tumours, including primary breast and colon tumour samples
- Its expression in tumours seems to be linked with Aurora-A kinase, suggesting a feedback mechanism between the two proteins.