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PIPA5101811

RAPGEF5 Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA5101811-Each-of-1 In Stock ₹ 46,502.50

PIPA5101811 - Each of 1

₹ 46,502.50

In Stock

Quantity

1

Base Price: ₹ 46,502.50

GST (18%): ₹ 8,370.45

Total Price: ₹ 54,872.95

Antigen

RAPGEF5

Classification

Polyclonal

Conjugate

Unconjugated

Gene

RAPGEF5

Gene Alias

4932413M22; C86120; D030051B22Rik; GFR; guanine nucleotide exchange factor; guanine nucleotide exchange factor for Rap1; KIAA0277; mKIAA0277; mmr-gef; Mras regulated guanine nucleotide exchange factor; M-Ras-regulated GEF; M-Ras-regulated Rap GEF; MRGEF; MR-GEF; Rap guanine nucleotide exchange factor (GEF) 5; Rap guanine nucleotide exchange factor 5; RAPGEF5; Related to Epac; REPAC; RGD1562891; rMR-GEF; tcag7.1034

Host Species

Rabbit

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

217944, 362799, 9771

Content And Storage

-20°C

Form

Liquid

Applications

Immunocytochemistry, Western Blot

Concentration

1 mg/mL

Formulation

PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.

P83900, Q8C0Q9, Q92565

Gene Symbols

RAPGEF5

Immunogen

A synthesized peptide derived from human RAPGEF5(Accession Q92565), corresponding to amino acid residues F521-E571.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human, Mouse, Rat

Product Type

Antibody

Isotype

IgG

Description

  • Antibody detects endogenous levels of total RAPGEF5
  • Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states
  • Guanine nucleotide exchange factors (GEFs), such as Repac, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation
  • Repac, also known as Rap guanine nucleotide exchange factor 5 (RAPGEF5), is a 580 amino acid protein that is expressed in brain and testis, with weaker expression in heart, placenta, lung, pancreas and small intestine
  • Existing as two alternatively spliced isoforms, the Repac gene is conserved in cow, mouse and rat
  • The gene that encodes Repac maps to human chromosome 7p15.3, with high expression of this region linking to positive response to erlotinib therapy for those with non-small-cell lung cancer.