CYP8B1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5102021-Each-of-1 | In Stock | ₹ 46,858.50 |
PIPA5102021 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,858.50
GST (18%): ₹ 8,434.53
Total Price: ₹ 55,293.03
Antigen
CYP8B1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CYP8B1
Gene Alias
7 alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase; 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase; 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; CP8B; CYP12; Cyp8b1; CYPVIIIB1; cytochrome P450 8B1; cytochrome P450 8b1 sterol 12 alpha-hydrolase; cytochrome P450 family 8 subfamily B member 1; cytochrome P450, 8b1, sterol 12 alpha-hydrolase; cytochrome P450, family 8, subfamily B, polypeptide 1; cytochrome P450, subfamily VIIIB (sterol 12-alpha-hydroxylase), polypeptide 1; sterol 12-alpha-hydrolase; sterol 12-alpha-hydroxylase
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
13124, 1582
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
O88962, Q9UNU6
Gene Symbols
CYP8B1
Immunogen
A synthesized peptide derived from human CYP8B1(Accession Q9UNU6), corresponding to amino acid residues G371-K421.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total Cytochrome P450 8B1
- CYP8B1 (sterol 12-alpha-hydroxylase) is a member of the cytochrome P450 superfamily of monooxygenase enzymes that are involved in the metabolism of a wide array of endogenous and xenobiotic compounds
- CYP8B1 is highly expressed in liver and is an important enzyme for bile acid synthesis
- Specifically, CYP8B1 moderates the ratio of cholic acid over chenodeoxycholic acid to control the solubility of cholesterol
- The gene encoding human CYP8B1 maps to chromosome 3p22.1
- The CYP8B1 gene encodes a 501-amino acid protein and does not contain any introns
- The CYP8B1 gene promoter is transactivated by hepatocyte nuclear factor 4a
- In mice, disruption of the CYP8B1 gene prevents the synthesis of cholate, which is a primary bile acid.