ATP6AP1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5102388-Each-of-1 | In Stock | ₹ 45,345.50 |
PIPA5102388 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,345.50
GST (18%): ₹ 8,162.19
Total Price: ₹ 53,507.69
Antigen
ATP6AP1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ATP6AP1
Gene Alias
16A; Ac45; AI316502; Atp6ap1; ATP6IP1; Atp6s1; ATPase H+ transporting accessory protein 1; ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1; ATPase, H+ transporting, lysosomal accessory protein 1; ATPase, H+ transporting, lysosomal interacting protein 1; AW108110; C7-1; C7-1 protein; CF2; H-ATPase subunit; mFLJ00383; MGC129781; protein C7-1; Protein XAP-3; vacuolar H+ ATPase accessory subunit 1; vacuolar proton pump subunit S1; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; V-ATPase subunit Ac45; V-ATPase subunit S1; VATPS1; V-type proton ATPase subunit S1; XAP3; XAP-3
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
537, 54411, 83615
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
O54715, Q15904, Q9R1Q9
Gene Symbols
ATP6AP1
Immunogen
A synthesized peptide derived from human ATP6AP1(Accession Q15904), corresponding to amino acid residues L91-V141.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total ATP6AP1
- Vacuolar-type H+-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles
- V-ATPases pump protons against an electrochemical gradient, thereby synthesizing ATP
- A peripheral V1 domain, which is responsible for ATP hydrolysis, and an integral V0 domain, which is responsible for proton translocation, compose the V-ATPase
- Nine subunits (A-H) make up the V1 domain and five subunits (a, d, c, c' and c"e"e) make up the V0 domain
- ATP6AP1 (ATPase, H+ transporting, lysosomal accessory protein 1), also known as 16A, CF2, Ac45, XAP3, ATP6S1, VATPS1 (vacuolar ATP synthase S1 accessory protein) or ATP6IP1, is a type I transmembrane, V-ATPase accessory protein that is predominantly expressed in endocrine and neuronal cells
- ATP6AP1 is responsible for targeting the V-ATPase enzyme to specialized complex vacuolar systems
- Via its cytoplasmic tail, ATP6AP1 interacts with subunits of the V0 domain
- The disruption of this interaction in osteoclasts results in impaired bone resorption, suggesting an important role for ATP6AP1 in proper osteoclastic bone resorption.