DNMT3L Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5102607-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5102607 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
DNMT3L
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DNMT3L
Gene Alias
cytosine-5-methyltransferase 3-like protein; D6Ertd14e; DNA (cytosine-5-)-methyltransferase 3-like; DNA (cytosine-5)-methyltransferase 3-like; DNA methyltransferase 3 like; Dnmt 3L; DNMT3L; ecat7; human cytosine-5-methyltransferase 3-like protein; MGC1090
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
29947, 54427
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q9CWR8, Q9UJW3
Gene Symbols
DNMT3L
Immunogen
A synthesized peptide derived from human DNMT3L(Accession Q9UJW3), corresponding to amino acid residues G132-V182.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total DNMT3L
- Methylation of DNA at cytosine residues in mammalian cells is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting, and development
- Three families of mammalian DNA methyltransferases have been identified: DNMT1, DNMT2, and DNMT3
- DNMT1 is constitutively expressed in proliferating cells and functions as a maintenance methyltransferase, transferring proper methylation patterns to newly synthesized DNA during replication
- DNMT3A and DNMT3B are strongly expressed in embryonic stem cells with reduced expression in adult somatic tissues
- DNMT3A and DNMT3B function as de novo methyltransferases that methylate previously unmethylated regions of DNA
- DNMT2 is expressed at low levels in adult somatic tissues and its inactivation affects neither de novo nor maintenance DNA methylation
- DNMT3L is a catalytically inactive regulatory factor for the DNMT3A and DNMT3B de novo methyltransferases that is expressed at low levels in embryonic stem cells, testis, ovaries, and thymus
- These de novo methyltransferases consist of a heterotetrameric complex containing two molecules of DNMT3L, and either two molecules of DNMT3A or DNMT3B
- DNMT3L contains an amino-terminal ATRX-DNMT3-DNMT3L (ADD) domain and a carboxy-terminal methyltransferase-like domain.